ABSTRACT
COVID-19 is a pandemic with over 5 million cases worldwide. The disease has imposed a huge burden on health resources. Evaluation of clinical and epidemiological profiles of such patients can help in understanding and managing the outbreak more efficiently. This study was a prospective observational analysis of 200 diagnosed COVID-19 patients admitted to a tertiary care center from 20th march to 8th May 2020. All these patients were positive for COVID-19 by an oro-nasopharyngeal swab-rtPCR based testing. Analyses of demographic factors, clinical characteristics, comorbidities, laboratory parameters, and the outcomes were performed. The mean age of the population was 40 years with a slight male predominance (116 patients out of 200, 58%). A majority of the patients (147, 73.5 %) were symptomatic, with fever being the most common symptom (109, 54.5%), followed by cough (91, 45.5%). An older age, presence of symptoms and their duration, leukocytosis, a high quick SOFA score, a high modified SOFA score, need for ventilator support, an AST level more than 3 times the upper limit of normal (ULN), and a serum creatinine level of 2 mg/dl or greater were at a significantly higher risk of ICU admission and mortality. Presence of diabetes mellitus, AST > three times ULN, serum creatinine 2 mg/dl or higher, and a qSOFA score of 1 or higher were all associated with significantly greater odds of critical care requirement. Triage and severity assessment helps in deciding the requirement for a hospital stay and ICU admission for COVID-19 which can easily be done using clinical and laboratory parameters. A mild, moderate and severe category approach with defined criteria and treatment guidelines will help in judicious utilization of health-care resources, especially for developing countries like India. *Other members of the Safdarjung Hospital COVID-19 working group: Balvinder Singh (Microbiology), MK Sen (Pulmonary Medicine), Shibdas Chakrabarti (Pulmonary Medicine), NK Gupta (Pulmonary medicine), AJ Mahendran (Pulmonary Medicine), Ramesh Meena (Medicine), G Usha (Anaesthesiology), Santvana Kohli (Anaesthesiology), Sahil Diwan (Anaesthesiology), Rushika Saksena (Microbiology), Vikramjeet Dutta (Microbiology), Anupam Kr Anveshi (Microbiology).
Subject(s)
Coronavirus Infections/blood , Coronavirus Infections/physiopathology , Pneumonia, Viral/blood , Pneumonia, Viral/physiopathology , Adolescent , Adult , Aged , Aged, 80 and over , Alanine Transaminase/blood , Anemia/blood , Aspartate Aminotransferases/blood , Betacoronavirus , COVID-19 , Child , Child, Preschool , Comorbidity , Coronary Artery Disease/epidemiology , Coronavirus Infections/mortality , Coronavirus Infections/therapy , Cough/physiopathology , Creatinine/blood , Diabetes Mellitus/epidemiology , Female , Fever/physiopathology , Humans , Hypertension/epidemiology , Hypoxia/physiopathology , India/epidemiology , Infant , Infant, Newborn , Intensive Care Units , Length of Stay , Leukocyte Count , Leukocytosis/blood , Lymphopenia/blood , Lymphopenia/physiopathology , Male , Middle Aged , Myalgia/physiopathology , Organ Dysfunction Scores , Pandemics , Pharyngitis/physiopathology , Platelet Count , Pneumonia, Viral/mortality , Pneumonia, Viral/therapy , Prospective Studies , Respiration, Artificial , SARS-CoV-2 , Tachypnea/physiopathology , Tertiary Care Centers , Time Factors , Tuberculosis/epidemiology , Young AdultSubject(s)
COVID-19/prevention & control , Infection Control/methods , Masks/standards , Occupational Exposure/prevention & control , Respiratory Tract Infections/prevention & control , Equipment Design , Health Personnel , Humans , Pneumonia, Viral/prevention & control , Respiratory Protective Devices/standardsABSTRACT
Not available.
Subject(s)
Betacoronavirus , Coronavirus Infections/therapy , Pneumonia, Viral/therapy , Prone Position/physiology , Respiration, Artificial/methods , Respiratory Distress Syndrome/therapy , Wakefulness , COVID-19 , Humans , Pandemics , SARS-CoV-2ABSTRACT
The corona virus disease 2019 (COVID-19) outbreak started in December 2019 in Wuhan, China, and spread all over the world leading to declaration of a pandemic by World Health Organization (WHO) on 11th March 2020. Most countries around the world have been on lockdown in an effort to halt the spread of virus. People around the world have been pushed into uncharted waters of uncertainty, fear, anxiety, stress and depression due to economic crash down, job losses and fear for their own health and that of their loved ones. There is a known association between anxiety/stress and sleep disturbances and vice versa. The most vulnerable population in this isolation like condition, in this lockdown, are the chief earning member of the family, women, young ones, and people with psychiatric illness.
Subject(s)
Coronavirus Infections/psychology , Pneumonia, Viral/psychology , Sleep Wake Disorders/etiology , Social Isolation/psychology , COVID-19 , Coronavirus Infections/prevention & control , Humans , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Sleep Hygiene , Sleep Wake Disorders/prevention & control , Sleep Wake Disorders/psychology , Stress, Psychological/complications , Stress, Psychological/etiologyABSTRACT
To the Editor Novel Coronavirus disease (COVID-19) was first notified in December 2019 from Wuhan, China. Now, it has spread rapidly and has been declared a pandemic affecting over 200 countries with widespread morbidity and mortality. It has been postulated that the most vulnerable population are the elderly, people living in crowded areas, children and immune-compromised individuals, such as people living with human immunodeficiency virus (HIV). The correlation of tuberculosis (TB), HIV and malnutrition are well documented and hence, people with tuberculosis should be considered as special population in this pandemic. TB is an ancient disease among humans recorded as far back as seventy thousand years which was declared a global public health emergency in 1993 by the World Health Organisation (WHO). India has the highest TB burden in the world.